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Dr. Holzman cited in Journal of Cataract and Refractive Surgery

posted Oct 10, 2015, 8:47 PM by Jen Weigel
Tuesday, August 18, 2015

Dear TLC Affiliate,

This is a quick update on our surgery protocols involving the use of Muro-128 ointment.   You likely have noticed we have been using this preoperatively for a few years.  This originated from Dr. Holzman's research using hyperosmotic agents to reduce epithelial disruptions during LASIK.  Epithelial defects can put the patient at risk for ingrowth, DLK, prolonged healing and undercorrection.

Attached is Dr. Holzman's article which recently was published in the May issue of Journal of Cataract and Refractive Surgery.  This is the first study of its kind investigating this issue.

Important points from the study:

  *   Age (>34yo) was shown to be the most significant risk factor for epithelial defects during LASIK.
  *   ​Use of preoperative hyperosmotic ointment reduced the incidence of epithelial defects during surgery.

Therefore, we have all patients over 35 years of age use Muro-128 ointment at bedtime one week before surgery.  Also patients with very fair complexion (i.e. red hair, Rosacea) are placed on similar protocols.  These instructions are provided to your patients during their consultation at TLC.

While impossible to prevent every surgical complication, our team is committed to maximizing patient safety.  We feel the use of Muro helps us achieve this goal.  As always please contact me or Dr. Holzman (<>) with any questions.

Thank you for your continued support!


Jen Weigel, O.D. , FAAO| Clinical Director | TLC Laser Eye Centers®